# A facile approach to preparing personalized cancer vaccines using iron-based metal organic framework

https://mdr.nims.go.jp/datasets/0ee96c6f-6c1c-4f8b-8477-1f7af87fd589

## File

- [2024 Front Immunol -Xia Li.pdf](https://mdr.nims.go.jp/filesets/7a657b6d-5bed-41fb-85bf-61bb52ec097c/download) ([Detail](https://mdr.nims.go.jp/filesets/7a657b6d-5bed-41fb-85bf-61bb52ec097c.md))

## Id

0ee96c6f-6c1c-4f8b-8477-1f7af87fd589

## Local identifier



## Visibility

open_to_public

## State

published

## Created at

2024-09-17T08:18:11.792085Z

## Updated at

2024-09-18T03:30:32.718097Z

## Published at

2024-09-18T03:30:32.797869Z

## Doi



## First published url

https://doi.org/10.3389/fimmu.2023.1328379

## Date published

2024-01-08

## Recorded date published



## Resource type

journal_article

## Manuscript type

vor

## Collection



## Title

- title: A facile approach to preparing personalized cancer vaccines using iron-based
    metal organic framework
  title_type: original
  lang: en

## Description

- description: Considering the diversity of tumors, it is of great significance to
    develop a simple, effective, and low-cost method to prepare personalized cancer
    vaccines. In this study, a facile one-pot synthetic route was developed to prepare
    cancer vaccines using model antigen or autologous tumor antigens based on the
    coordination interaction between Fe3+ ions and endogenous fumarate ligands. Herein,
    Fe-based metal organic framework can effectively encapsulate tumor antigens with
    high loading efficiency more than 80%, and act as both delivery system and adjuvants
    for tumor antigens. By adjusting the synthesis parameters, the obtained cancer
    vaccines are easily tailored from microscale rod-like morphology with lengths
    of about 0.8 μm (OVA-ML) to nanoscale morphology with sizes of about 50~80 nm
    (OVA-MS). When cocultured with antigen-presenting cells, nanoscale cancer vaccines
    more effectively enhance antigen uptake and Th1 cytokine secretion than microscale
    ones. Nanoscale cancer vaccines (OVA-MS, dLLC-MS) more effectively enhance lymph
    node targeting and cross-presentation of tumor antigens, mount antitumor immunity,
    and inhibit the growth of established tumor in tumor-bearing mice, compared with
    microscale cancer vaccines (OVA-ML, dLLC-ML) and free tumor antigens. Our work
    paves the ways for a facile, rapid, and low-cost preparation approach for personalized
    cancer vaccines.
  description_type: abstract
  lang: und

## Creator

- name: Xia Li
  role: author
  orcid: https://orcid.org/0000-0002-3246-4462
  organization: National Institute for Materials Science
- name: Shinya Hattori
  role: author
  orcid: https://orcid.org/0000-0002-2635-2464
  organization: National Institute for Materials Science
- name: Mitsuhiro Ebara
  role: author
  orcid: https://orcid.org/0000-0002-7906-0350
  organization: National Institute for Materials Science
- name: Naoto Shirahata
  role: author
  orcid: https://orcid.org/0000-0002-1217-7589
  organization: National Institute for Materials Science
- name: Nobutaka Hanagata
  role: author
  orcid: https://orcid.org/0000-0001-6079-3426
  organization: National Institute for Materials Science

## Contact agent



## Publisher

organization: Frontiers Media SA

## Managing organization



## Keyword

- subject: cancer immunotherapy
  schema: not_defined
- subject: personalized cancer vaccines
  schema: not_defined
- subject: metal organic framework
  schema: not_defined
- subject: ferric ions
  schema: not_defined
- subject: endogenous fumurate ligands
  schema: not_defined
- subject: nanotechnology
  schema: not_defined
- subject: adjuvants
  schema: not_defined

## Rights

- identifier: https://creativecommons.org/licenses/by/4.0/

## Other identifier(s)



## Data origin



## Embargo



## Journal

- title: Frontiers in Immunology
  issn: '16643224'
  volume: '14'
  article_number: '1328379'

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## Fileset

- id: 7a657b6d-5bed-41fb-85bf-61bb52ec097c
  filename: 2024 Front Immunol -Xia Li.pdf
  content_type: application/pdf
  size: 4248396
  md5: a9275fa5a59a7f02d6894ab344b3608c

## Thumbnail

fileset_id: 7a657b6d-5bed-41fb-85bf-61bb52ec097c
filename: 2024 Front Immunol -Xia Li.pdf