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Considering the diversity of tumors, it is of great significance to develop a simple, effective, and low-cost method to prepare personalized cancer vaccines. In this study, a facile one-pot synthetic route was developed to prepare cancer vaccines using model antigen or autologous tumor antigens based on the coordination interaction between Fe3+ ions and endogenous fumarate ligands. Herein, Fe-based metal organic framework can effectively encapsulate tumor antigens with high loading efficiency more than 80%, and act as both delivery system and adjuvants for tumor antigens. By adjusting the synthesis parameters, the obtained cancer vaccines are easily tailored from microscale rod-like morphology with lengths of about 0.8 μm (OVA-ML) to nanoscale morphology with sizes of about 50~80 nm (OVA-MS). When cocultured with antigen-presenting cells, nanoscale cancer vaccines more effectively enhance antigen uptake and Th1 cytokine secretion than microscale ones. Nanoscale cancer vaccines (OVA-MS, dLLC-MS) more effectively enhance lymph node targeting and cross-presentation of tumor antigens, mount antitumor immunity, and inhibit the growth of established tumor in tumor-bearing mice, compared with microscale cancer vaccines (OVA-ML, dLLC-ML) and free tumor antigens. Our work paves the ways for a facile, rapid, and low-cost preparation approach for personalized cancer vaccines.

権利情報:

• Creative Commons BY Attribution 4.0 International
  

キーワード: cancer immunotherapy, personalized cancer vaccines, metal organic framework, ferric ions, endogenous fumurate ligands, nanotechnology, adjuvants

刊行年月日: 2024-01-08

出版者: Frontiers Media SA

掲載誌:

• Frontiers in Immunology (ISSN: 16643224) vol. 14 1328379

研究助成金:

原稿種別: 出版者版 (Version of record)

MDR DOI:

公開URL: https://doi.org/10.3389/fimmu.2023.1328379

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更新時刻: 2024-09-18 12:30:32 +0900

MDRでの公開時刻: 2024-09-18 12:30:32 +0900