# Exploring anti-cancer activities of epidermal growth factor-immobilized polymeric nanoparticles

https://mdr.nims.go.jp/datasets/0d476b24-91ff-4501-bff3-307af37c3176

## File

- [Exploring anti-cancer activities of epidermal.pdf](https://mdr.nims.go.jp/filesets/5a3a98db-2d57-4b51-ae0c-4565129b4f6d/download) ([Detail](https://mdr.nims.go.jp/filesets/5a3a98db-2d57-4b51-ae0c-4565129b4f6d.md))

## Id

0d476b24-91ff-4501-bff3-307af37c3176

## Local identifier



## Visibility

open_to_public

## State

published

## Created at

2025-03-06T04:20:45.490405Z

## Updated at

2025-03-06T23:30:11.172869Z

## Published at

2025-03-06T23:30:12.350349Z

## Doi



## First published url

https://doi.org/10.1080/14686996.2025.2463316

## Date published

2025-12-31

## Recorded date published

2025-12-31

## Resource type

journal_article

## Manuscript type

vor

## Collection



## Title

- title: Exploring anti-cancer activities of epidermal growth factor-immobilized polymeric
    nanoparticles
  title_type: original
  lang: en

## Description

- description: 'Cytotoxic agents targeting the epidermal growth factor receptor (EGFR)
    exhibit significant potential for cancer therapy as EGFR is overexpressed in various
    cancers. As alternatives to conventional EGFR inhibitors (EGFRi), which exert
    side effects on non-cancer cells, EGF-immobilized gold nanoparticles exhibit selective
    cytotoxicity in EGFR-overexpressing cancer cells by locally enhancing EGFR activation
    and modulating signal transduction through a signal condensation mechanism. However,
    considering real therapeutic applications, it is important to confirm that the
    same principle can be applied to polymeric nanoparticles, which are more suitable
    carriers owing to their biodegradability and biocompatibility, remains unclear.
    Therefore, in this study, we aimed to investigate the anti-cancer activities of
    EGF-conjugates with two kinds of polymeric nanoparticles: polystyrene nanoparticles
    and polymeric micelles. Initial mechanistic studies on phosphorylation signaling
    and cholesterol depletion revealed that EGF-polystyrene nanoparticles exhibited
    cytotoxicity against human cervical adenocarcinoma HeLa cells via local enhancement
    of EGFR activity in membrane rafts. Moreover, EGF-polymeric micelles exerted selective
    anti-cancer effects against EGFRi-resistant MDA-MB468 refractory triple-negative
    breast cancer cells after optimization of particle size. These results suggest
    that the unique anti-cancer effects of EGF nanoparticles are not dependent on
    the carrier platform. Furthermore, EGF nanoparticles exhibited high cytotoxicity
    against cancer cells responding poorly to conventional EGFR-targeted anti-cancer
    drugs, showing potential for future medical applications. Epidermal growth factor
    (EGF)-immobilized polymeric nanoparticles demonstrated anti-cancer activity in
    cancer cells that respond poorly to conventional EGF receptor-targeted anti-cancer
    drugs, indicating promising potential for medical applications.'
  description_type: abstract
  lang: und

## Creator

- name: Shota Yamamoto
  role: author
  orcid: https://orcid.org/0000-0002-7422-0968
- name: Chia-Jung Chang
  role: author
- name: Masao Kamimura
  role: author
  orcid: https://orcid.org/0000-0001-8510-2935
- name: Jun Nakanishi
  role: author
  orcid: https://orcid.org/0000-0003-4457-6581

## Contact agent



## Publisher

organization: Informa UK Limited

## Managing organization



## Keyword

- subject: Anti-cancer drugs
  schema: not_defined
- subject: EGF-nanoparticle conjugates
  schema: not_defined
- subject: Polymeric micelles
  schema: not_defined
- subject: Triple-negative breast cancer
  schema: not_defined

## Rights

- identifier: https://creativecommons.org/licenses/by/4.0/

## Other identifier(s)



## Data origin

- data_origin_type: other

## Embargo



## Journal

- title: Science and Technology of Advanced Materials
  issn: '14686996'
  volume: '26'
  issue: '1'

## Conference



## Related item



## Funding

- identifier: 22K14705
  funder_name: Japan Society for the Promotion of Science
- identifier: 23K17481
  funder_name: Japan Society for the Promotion of Science
- identifier: JP22ym0126803
  funder_name: AMED

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## Measurement method



## Specimen



## Chemical composition



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## Fileset

- id: 5a3a98db-2d57-4b51-ae0c-4565129b4f6d
  filename: Exploring anti-cancer activities of epidermal.pdf
  content_type: application/pdf
  size: 4363772
  md5: 00becd3f0fab729c9c7d5e91be79be37

## Thumbnail

fileset_id: 5a3a98db-2d57-4b51-ae0c-4565129b4f6d
filename: Exploring anti-cancer activities of epidermal.pdf