# Electrospun EVOH/AST-120 hybrid nanofiber membranes for removal of indoxyl sulfate from blood

https://mdr.nims.go.jp/datasets/0b735c68-b0b5-4ec0-befc-ac2398bf69a9

## File

- [d4ra04501g (1).pdf](https://mdr.nims.go.jp/filesets/91da2589-8f13-457b-b746-2b11aaa53d7d/download) ([Detail](https://mdr.nims.go.jp/filesets/91da2589-8f13-457b-b746-2b11aaa53d7d.md))

## Id

0b735c68-b0b5-4ec0-befc-ac2398bf69a9

## Local identifier



## Visibility

open_to_public

## State

published

## Created at

2025-01-21T01:26:08.132734Z

## Updated at

2025-01-29T07:30:18.813990Z

## Published at

2025-01-29T07:30:19.828041Z

## Doi



## First published url

https://doi.org/10.1039/d4ra04501g

## Date published

2024-08-22

## Recorded date published

2024-8-16

## Resource type

journal_article

## Manuscript type

vor

## Collection



## Title

- title: Electrospun EVOH/AST-120 hybrid nanofiber membranes for removal of indoxyl
    sulfate from blood
  title_type: original
  lang: en

## Description

- description: Nanofibers containing activated carbon using poly(ethylene-co-vinyl
    alcohol) (EVOH) were prepared to remove indoxyl sulfate (IS) from the blood. IS
    is a urinary toxin that is highly toxic and triggers the progression of chronic
    kidney disease (CKD). Here, nanofibers containing activated carbon (AST-120),
    which has been used practically as an adsorbent for indole (a precursor of IS),
    were fabricated via electrospinning for the adsorption and removal of IS from
    the blood. EVOH containing different ethylene ratios was used as the nanofiber
    material; moreover, the effect of the ethylene ratio on various properties of
    the nanofibers, such as surface wettability and the IS adsorption rate, was investigated.
    As a result, EVOH/AST-120 nanofibers comprising EVOH with a low ethylene ratio
    exhibited faster IS adsorption behavior. This adsorption behavior agreed well
    with the pseudo-second-order model, suggesting that the diffusion of IS into the
    nanofibers is the rate-limiting step of the process of adsorption. Furthermore,
    the nanofibers successfully reduced the IS concentration in the blood under circulating
    conditions. Therefore, these EVOH/AST-120 nanofibers are expected to greatly improve
    the prognosis of patients with CKD when used in combination with the current hemodialysis
    therapy as an IS-adsorbing filter.
  description_type: abstract
  lang: und

## Creator

- name: Makoto Sasaki
  role: author
  orcid: https://orcid.org/0000-0002-7696-6405
  organization: National Institute for Materials Science
  ror: https://ror.org/026v1ze26
- name: Rieko Hirata
  role: author
- name: Ayano Konagai
  role: author
- name: Mitsuhiro Ebara
  role: author
  orcid: https://orcid.org/0000-0002-7906-0350
  organization: National Institute for Materials Science
  ror: https://ror.org/026v1ze26

## Contact agent



## Publisher

organization: Royal Society of Chemistry (RSC)

## Managing organization



## Keyword

- subject: Electrospinning
  schema: not_defined
- subject: Nanofiber
  schema: not_defined
- subject: Chronic Kidney Disease
  schema: not_defined
- subject: Indoxyl sulfate
  schema: not_defined
- subject: Hybrid maerial
  schema: not_defined

## Rights

- identifier: https://creativecommons.org/licenses/by-nc/3.0/legalcode

## Other identifier(s)



## Data origin

- data_origin_type: other

## Embargo



## Journal

- title: RSC Advances
  issn: '20462069'
  volume: '14'
  issue: '36'
  start_page: 26596
  end_page: 26603

## Conference



## Related item



## Funding

- funder_name: Ministry of Education, Culture, Sports, Science and Technology
- identifier: JP20H05877
  funder_name: Japan Society for the Promotion of Science
- identifier: JP23KJ0260
  funder_name: Japan Society for the Promotion of Science

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## Measurement method



## Specimen



## Chemical composition



## Structure for specimen



## Structural feature for specimen



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## Process for specimen treatment



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## Fileset

- id: 91da2589-8f13-457b-b746-2b11aaa53d7d
  filename: d4ra04501g (1).pdf
  content_type: application/pdf
  size: 1546636
  md5: ddb8cc8dafd7c5bfc707228813b22b84

## Thumbnail

fileset_id: 91da2589-8f13-457b-b746-2b11aaa53d7d
filename: d4ra04501g (1).pdf