# Understanding the influence of HEPES buffer concentration on the biodegradation of pure magnesium: An electrochemical study

https://mdr.nims.go.jp/datasets/0b43dd4a-4cd2-42e4-8c37-8ef3761d4b02

## File

- [Manuscript160510.pdf](https://mdr.nims.go.jp/filesets/bcf7ebd1-68f6-4199-96e4-67f614c2d5e0/download) ([Detail](https://mdr.nims.go.jp/filesets/bcf7ebd1-68f6-4199-96e4-67f614c2d5e0.md))
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## Id

0b43dd4a-4cd2-42e4-8c37-8ef3761d4b02

## Local identifier



## Visibility

open_to_public

## State

published

## Created at

2025-09-17T10:30:15.562895Z

## Updated at

2025-09-18T03:30:27.754108Z

## Published at

2025-09-18T03:23:04.083594Z

## Doi

https://doi.org/10.48505/nims.5770

## First published url

https://doi.org/10.1016/j.matchemphys.2017.05.024

## Date published

2017-05-16

## Recorded date published

2017-8

## Resource type

journal_article

## Manuscript type

accepted_manuscript

## Collection



## Title

- title: 'Understanding the influence of HEPES buffer concentration on the biodegradation
    of pure magnesium: An electrochemical study'
  title_type: original
  lang: en

## Description

- description: A systematic electrochemical study was performed to understand the
    influence of HEPES buffer concentration on the degradation behaviour of pure magnesium
    in Earle’s balanced salt solution (EBSS). Electrochemical impedance spectroscopy
    and potentiodynamic polarisation experiments suggest that HEPES accelerates the
    degradation of magnesium. While 5% CO2 in EBSS reduced the polarisation resistance
    of magnesium by ~79%, addition of HEPES (25 mM) to EBSS decreased the Rp of magnesium
    by ~98% and escalated the corrosion current by over an order of magnitude as compared
    to that in EBSS. Increase in HEPES concentration (50 and 100 mM) further increased
    the degradation of magnesium. Interestingly, the bulk pH difference between EBSS
    + HEPES and EBSS + CO2, before and after the electrochemical testing, was only
    marginal. However, the polarisation curves and FTIR spectroscopy analysis suggest
    that HEPES affected the formation of insoluble salt layer (phosphate and carbonate)
    on the surface of magnesium. This effect can be attributed to the increase in
    the ionic strength of the solution due to HEPES addition.
  description_type: abstract
  lang: und

## Creator

- name: M. Bobby Kannan
  role: author
- name: Hadis Khakbaz
  role: author
- name: A. Yamamoto
  role: author
  orcid: https://orcid.org/0000-0002-9182-4886
  organization: National Institute for Materials Science

## Contact agent



## Publisher

organization: Elsevier BV

## Managing organization



## Keyword

- subject: Magnesium
  schema: not_defined
- subject: Biomaterials
  schema: not_defined
- subject: Degradation
  schema: not_defined
- subject: HEPES
  schema: not_defined
- subject: EBSS
  schema: not_defined

## Rights

- identifier: https://creativecommons.org/licenses/by-nc-nd/4.0/

## Other identifier(s)



## Data origin

- data_origin_type: other

## Embargo

start_date: 2017-05-16
end_date: 2019-05-16

## Journal

- title: Materials Chemistry and Physics
  issn: '02540584'
  volume: '197'
  start_page: 47
  end_page: 56

## Conference



## Related item



## Funding



## Instrument



## Instrument operator



## Instrument managing organization



## Measurement method



## Specimen



## Chemical composition



## Structure for specimen



## Structural feature for specimen



## Specific property for specimen



## Process for specimen treatment



## Computational method



## Energy level/transition state



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## Custom property



## Fileset

- id: bcf7ebd1-68f6-4199-96e4-67f614c2d5e0
  filename: Manuscript160510.pdf
  content_type: application/pdf
  size: 574572
  md5: 59317864c715dd5d6a865b33225a7f1d
- id: 622ffadc-8abb-4d3d-966c-a47602e87793
  filename: Figures160510.pdf
  content_type: application/pdf
  size: 1168598
  md5: df5bad0b4116cfb2112ec0d2ac5cf66d

## Thumbnail

fileset_id: bcf7ebd1-68f6-4199-96e4-67f614c2d5e0
filename: Manuscript160510.pdf