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Physiomimetic Fluidic Culture Platform on Microwell-Patterned Porous Collagen Scaffold for Human Pancreatic Islets

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Pancreatic islet transplantation is one of the clinical options for certain types of diabetes. However, difficulty in maintaining islets prior to transplantation limits the clinical expansion of islet transplantations. Our study introduces a dynamic culture platform developed specifically for primary human islets by mimicking the physiological microenvironment, including tissue fluidics and extracellular matrix support. We engineered the dynamic culture system by incorporating our distinctive microwell-patterned porous collagen scaffolds for loading isolated human islets, enabling vertical medium flow through the scaffolds. The physiological microenvironment-mimetic culture platform supported the viability and quality of isolated human islets at high-seeding density.

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Date published
  • 14/05/2024
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Journal
  • Title
    Cell Transplantation
    ISSN
    09636897
    Article number
    49556
    Volume
    33
    Start page
    49556
    End page
    49556
Manuscript type
  • Version of record (Published version)
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Funding reference
  • Funder identifier
    R03DK129958-01
    Funder name
    National Institutes of Health
    Funder name
    Nora Eccles Treadwell Foundation
    Funder identifier
    3-SRA-2021-1073-S-B
    Funder name
    JDRF
    Funder identifier
    P30CA033572
    Funder name
    National Institutes of Health
    Funder identifier
    P30CA033572
    Funder name
    National Cancer Institute of the National Institutes of Health
    Funder identifier
    22K19926
    Funder name
    Japan Society for the Promotion of Science

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