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Scaffolds functionalized with matrix metalloproteinase-responsive release of miRNA for synergistic magnetic hyperthermia and sensitizing chemotherapy of drug-tolerant breast cancer
In this study, multifunctional scaffolds were designed to efficiently treat drug-tolerant breast cancer by improving the sensitization of breast cancer cells and synchronizing anticancer drug release with magnetic hyperthermia. The scaffolds contained microRNA-encapsulated matrix metalloproteinase-cleavable liposomes, doxorubicin-encapsulated thermoresponsive liposomes and Fe3O4 nanoparticles. The scaffolds released microRNA specifically to improve the sensitization of breast cancer cells to anticancer drugs, and also showed excellent hyperthermia effects under alternating magnetic field irradiation. In vitro and in vivo studies demonstrated that the scaffolds effectively reduced drug resistance and eliminated doxorubicin-tolerant MDA-MB-231 cells through the synergistic effect of magnetic hyperthermia and sensitizing chemotherapy. Additionally, the scaffolds supported the proliferation and adipogenic differentiation of stem cells for adipose tissue regeneration after killing cancer.
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- 19/10/2024
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Scaffolds functionalized with matrix metalloproteinase-responsive release.pdf | 12.2 MB | MDR Open |
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