Publication
Surface charge-dependent cytokine production using near-infrared emitting silicon quantum dots
This article outlines the preparation of three distinct surface-charged SiQDs-F127 (+0.03, + 9.13, -7.05 mV), varying from negative to positive charges. Depending on the surface charges, the amount of CpG ODNs also varies; positively charged materials take up more ODNs (-44.31 mV) than neutral (-37.10 mV) and negatively charged (-30.00 mV) materials due to electrostatic attraction. We assessed the viability of the cells, as well as their uptake and localization in endosomes. PSiQDs with a positive charge are more localized and induce higher levels of cytokines, including IL-6 and IFN-α, due to increased endosomal localization compared to other surface-charged PSiQDs. The results indicate that the surface charges of the nanoparticle play a significant role in delivering CpG ODN2006x3-PD and inducing cytokines.
- First published at
- Creator
- Keyword
- Resource type
- Publisher
- Date published
- 26/04/2024
- Rights statement
- License description
- Journal
- Manuscript type
- Version of record (Published version)
- Language
- Funding reference
Items
Thumbnail | Title | Date Uploaded | Size | Visibility | Actions |
---|---|---|---|---|---|
|
Scientific Reports 2024, 14, 9618.pdf | 7.69 MB | MDR Open |
|