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Surface charge-dependent cytokine production using near-infrared emitting silicon quantum dots

MDR Open Deposited

This article outlines the preparation of three distinct surface-charged SiQDs-F127 (+0.03, + 9.13, -7.05 mV), varying from negative to positive charges. Depending on the surface charges, the amount of CpG ODNs also varies; positively charged materials take up more ODNs (-44.31 mV) than neutral (-37.10 mV) and negatively charged (-30.00 mV) materials due to electrostatic attraction. We assessed the viability of the cells, as well as their uptake and localization in endosomes. PSiQDs with a positive charge are more localized and induce higher levels of cytokines, including IL-6 and IFN-α, due to increased endosomal localization compared to other surface-charged PSiQDs. The results indicate that the surface charges of the nanoparticle play a significant role in delivering CpG ODN2006x3-PD and inducing cytokines.

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  • 26/04/2024
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